Association of SIRT1 with metabolic parameters and aging rate

Introduction: SIRT1 has attracted great interest due to its role as a regulator of longevity, and therapeutic potential for the prevention treatment aging age-related comorbidities. However, mechanisms by which influences course remain unknown. Methods: The study population included 88 apparently healthy subjects aged 31 – 65 without established atherosclerotic cardiovascular disease or metabolic-associated diseases. Clinical, anthropometric, biochemical parameters were determined in all patients. Molecular genetic studies determination C/G polymorphism gene (SIRT1, rs7069102), relative telomere length blood leukocytes (RTL-b), telomerase activity. Biological age was calculated using DNAm PhenoAge epigenetic clock. Results: serum levels carriers different genotypes G/C (rs7069102) patients groups did not differ. plasma accelerated group significantly higher comparison with group: (4.16 ± 1.18) ng/ml vs (3.47 0.76) ng/ml, respectively (p = 0.00066). Correlation analysis revealed positive correlation level uric acid (R 0.25; p 0.023), tissue necrosis factor 0.26; 0.014), total hydroperoxides 0.33; 0.003) negative low-density lipoprotein cholesterol -0.22; 0.039), activity -0.39; 0.001) antioxidant -0.35; 0.001). Stepwise regression association biological age. Conclusion: associated age, body mass index (BMI), WC, factors carbohydrate metabolism, markers pro-antioxidant balance. A comparative between showed significant difference. our confirm that SNPs are level, rate, any metabolic parameters.